CIDER: Resources to analyze sequence-ensemble relationships of intrinsically disordered proteins
Biophys. J. 112, 16-21. (2017)
Holehouse, A.S.* Ahad, J., Das, RK., Richardson, MOG., Pappu RV.* (* - co-corresponding authors)
CIDER and localCIDER are two related but independent tools I developed for sequence analysis. CIDER is a webserver for the analysis of disordered sequences. It provides a quick and easy way to obtain sequence information, including phase digram classification, net charge per residue, fraction of charged resdiues, and kappa. localCIDER is a Python toolkit (installabled via
pip install localcider) that provides a large set of sequence analysis tools for disordered proteins.
This paper outlines these tools and some of the analysis and insights that can be gained through their use. In addition, the supplementary information contains a full analysis of the complete set of disordered regions from 14 different model organisms, as well as an extensive discussion on the sequence patterning parameter kappa.