Developing a novel integrated model of p38 MAPK and glucocorticoid signalling pathways
IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology pp. 69-76. (2012)
Holehouse, A., Yang, X., Adcock, I., and Guo, Y.
In this paper I developed a formal method for combining one or more signalling networks into a single, integrated model. Using this approach, I construct an integrative model to describe p38 MAPK signalling in response to the glucocorticoid receptor stimulation, and identified the key control nodes within the network to assess the impact of cross-talk between two signalling pathways that had previously been considered largely discrete.